Hijacking through mimicry

Abstract

117 Written by Beth Moorefield, Arianne Heinrichs & Stéphane Larochelle developmental regulators were upregulated. Knockdown cells also showed increased RNA stability, whereas m6A-modified mRNAs showed accelerated decay rates. To gain insight into the underlying mechanism, the authors focused on the RNA-stabilizing protein HuR and noted an inverse correlation between HuR binding and m6Amodified RNA in knockdown cells. Indeed, RNA stability of an m6A target mRNA, but not control transcripts that were not m6A targets or lacked HuR-binding sites, was regulated in a HuR-dependent manner. HuR also increased RNA stability of Mettl3 or Mettl14 targets in knockdown cells by blocking microRNA targeting. Together, these data imply that the presence of m6A methylation in some transcripts, particularly those encoding developmental regulators, blocks HuR binding and destabilizes them, thereby maintaining the mESC ground state. (Nat. Cell Biol. doi:10.1038/ncb2902, 7 January 2014) AH DnA break repair goes live

DOI: 10.1038/nsmb.2774

Cite this paper

@article{Larochelle2014HijackingTM, title={Hijacking through mimicry}, author={St{\'e}phane Larochelle}, journal={Nature Structural &Molecular Biology}, year={2014}, volume={21}, pages={117-117} }