Hijacking of the Host SCF Ubiquitin Ligase Machinery by Plant Pathogens

  title={Hijacking of the Host SCF Ubiquitin Ligase Machinery by Plant Pathogens},
  author={Shimpei Magori and Vitaly Citovsky},
  booktitle={Front. Plant Sci.},
The SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex mediates polyubiquitination of proteins targeted for degradation, thereby controlling a plethora of biological processes in eukaryotic cells. Although this ubiquitination machinery is found and functional only in eukaryotes, many non-eukaryotic pathogens also encode F-box proteins, the critical subunits of the SCF complex. Increasing evidence indicates that such non-eukaryotic F-box proteins play an essential role in subverting or… CONTINUE READING
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