Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

@inproceedings{Gloster2011HijackingAB,
  title={Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells},
  author={Tracey M Gloster and Wesley F Zandberg and Julia E. Heinonen and David L. Shen and Lehua Deng and David J Vocadlo},
  booktitle={Nature chemical biology},
  year={2011}
}
Glycosyltransferases are ubiquitous enzymes that catalyze the assembly of glycoconjugates throughout all kingdoms of nature. A long-standing problem is the rational design of probes that can be used to manipulate glycosyltransferase activity in cells and tissues. Here we describe the rational design and synthesis of a nucleotide sugar analog that inhibits, with high potency both in vitro and in cells, the human glycosyltransferase responsible for the reversible post-translational modification… CONTINUE READING
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