Highs and lows of hyperoxia: physiological, performance, and clinical aspects.

  title={Highs and lows of hyperoxia: physiological, performance, and clinical aspects.},
  author={Julien Vincent Brugniaux and Geoff B. Coombs and Otto F. Barak and Zeljko Dujic and Mypinder S. Sekhon and Philip N. Ainslie},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={315 1},
  • J. Brugniaux, G. Coombs, P. Ainslie
  • Published 1 July 2018
  • Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
Molecular oxygen (O2) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Although normobaric hyperoxia can increase arterial oxygen content ([Formula: see text]), it also causes vasoconstriction and hence reduces O2 delivery in various vascular beds, including the heart, skeletal muscle, and brain. Thus, a seemingly paradoxical situation exists in which the administration of oxygen may place tissues at increased risk of… 

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