Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity.

@article{Taubert2007HighlyVE,
  title={Highly variable expression of tissue-restricted self-antigens in human thymus: implications for self-tolerance and autoimmunity.},
  author={R Dieter Taubert and Jochen Schwendemann and Bruno Kyewski},
  journal={European journal of immunology},
  year={2007},
  volume={37 3},
  pages={838-48}
}
Induction of T cell tolerance in the thymus (central tolerance) is essential for preventing organ-specific autoimmunity. This apparent paradox is in part explained by promiscuous expression of numerous tissue-restricted self-antigens (TRA) in medullary thymic epithelial cells (mTEC), which is highly conserved between mice and man. In animal models, the threshold of central tolerance towards such TRA is surprisingly sensitive towards minor shifts in antigen expression levels and this might also… CONTINUE READING

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