Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis.

  title={Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis.},
  author={Imad J. Matouk and Ibrahim Abbasi and Abraham Hochberg and Eithan Galun and Hassan Dweik and Mutaz Akkawi},
  journal={European journal of gastroenterology & hepatology},
  volume={21 6},
BACKGROUND The highly upregulated in liver cancer (HULC) gene transcribes to an mRNA-like noncoding RNA (ncRNA) by the RNA polymerase II and processed by capping, splicing and polyadenylation. It is specifically expressed in the hepatocytes with striking upregulation in hepatocellular carcinoma (HCC). OBJECTIVES To study the expression levels of HULC in normal colorectal samples, primary colorectal carcinomas and in secondary tumors formed from colorectal carcinomas that metastasize to either… CONTINUE READING


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