Corpus ID: 4451110

Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice.

  title={Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice.},
  author={M. B. Petrik and M. Mcentee and B. T. Johnson and M. Obukowicz and J. Whelan},
  journal={The Journal of nutrition},
  volume={130 10},
We showed previously that dietary eicosapentaenoic acid [EPA, 20:5(n-3)] is antitumorigenic in the APC:(Min/+) mouse, a genetic model of intestinal tumorigenesis. Only a few studies have evaluated the effects of dietary fatty acids, including EPA and docosahexaenoic acid [DHA, 22:6(n-3)], in this animal model and none have evaluated the previously touted antitumorigenicity of alpha-linolenic acid [ALA, 18:3(n-3)], conjugated linoleic acid [CLA, 77% 18:2(n-7)], or gamma-linolenic acid [GLA, 18:3… Expand
Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits.
  • J. Whelan
  • Biology, Medicine
  • The Journal of nutrition
  • 2009
The comparative results suggest that SDA shares many of the biological effects of (n-3) LCPUFA and functions most similarly to dietary EPA compared with ALA when consumed in a typical Western diet, and could become a prominent surrogate for EPA in the commercial development of foods fortified with (n)-3) PUFA. Expand
Conjugated linoleic acid metabolism
  • S. Banni
  • Biology, Medicine
  • Current opinion in lipidology
  • 2002
Conjugated linoleic acid is a naturally occurring fatty acid that is produced by a bio-hydrogenation process in the rumen, and thus is present in dairy products and ruminant meat and there are evidences supporting the hypothesis that CLA metabolism may interfere with eicosanoid formation. Expand
Comparison of the effects of dietary α-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice
The effects of dietary stearidonic acid (18∶4n−3) on inflammatory mediator release in whole blood and splenocytes was investigated in Balb/c mice, and the effects were compared with those of twoExpand
Highly Purified Eicosapentaenoic Acid as Free Fatty Acids Strongly Suppresses Polyps in ApcMin/+ Mice
The data make 99% pure EPA-FFA an excellent candidate for CRC chemoprevention, and a significant decrease in proliferation throughout the intestine together with an increase in apoptosis. Expand
A novel bioactive derivative of eicosapentaenoic acid (EPA) suppresses intestinal tumor development in Apc&Dgr;14/+ mice
Administration of TP-252 significantly reduced tumor number and size in the small intestine and colon in a dose-related manner and as effectively as EPA-FFA, indicating that TP- 252 warrants further clinical development as a potential strategy for delaying colectomy in adolescent FAP patients. Expand
Linseed oil in the maternal diet during gestation and lactation modifies fatty acid composition, mucosal architecture, and mast cell regulation of the ileal barrier in piglets.
In conclusion, linseed oil supplementation of the maternal diet profoundly modifies the fatty acid composition, structure, and physiology of the offspring ileum. Expand
Dietary omega-3 PUFA and health: stearidonic acid-containing seed oils as effective and sustainable alternatives to traditional marine oils.
  • M. Surette
  • Biology, Medicine
  • Molecular nutrition & food research
  • 2013
New plant-derived sources of omega-3 PUFA like stearidonic acid-soy oil from genetically modified soybeans and Ahiflower oil from Buglossoides arvensis seeds that are enriched in the 18-carbon omega- 3 PUFA stearIDonic acid are being developed and show promise to become effective as well as sustainable sources of Omega-3PUFA. Expand
Interaction of Conjugated Linoleic Acid, Sphingomyelin, and Butyrate on Formation of Colonic Aberrant Crypt Foci and Immune Functions in Rats
Results show that the three compounds may not act addi-tively or synergistically either to inhibit the development of aberrant crypts or to enhance immune functions, and exposure to the combined compounds may be antagonistic to enhancement of NK function by the individual chemicals. Expand
Stearidonic acid-enriched flax oil reduces the growth of human breast cancer in vitro and in vivo
The 20 and 22 carbon n-3 long-chain polyunsaturated fatty acids (LCPUFA) inhibit the growth of tumors in vitro and in animal models, but less is known about the 18 carbon n-3, stearidonic acid (SDA).Expand
Dietary ( n6 ) PUFA and Intestinal Tumorigenesis 1 , 2
Cancer is the second leading cause of death in the United States, and mortality due to colorectal cancer is only surpassed by lung cancer. Epidemiological studies demonstrate that dietaryExpand