Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity.

@article{Zhang2006HighlyST,
  title={Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity.},
  author={Chaowei Zhang and John G. Ondeyka and Kithsiri b. Herath and Ziqiang Guan and J. G. S{\'a}nchez Collado and Fernando F Pelaez and Penny Sue Leavitt and Anne M. Gurnett and Bakela Nare and Paul A. Liberator and S Bhaskar Singh},
  journal={Journal of natural products},
  year={2006},
  volume={69 4},
  pages={710-2}
}
Parasite cGMP-dependent protein kinase (PKG) is one of the validated biochemical targets for the treatment of coccidiosis. We screened our library of natural product extracts for inhibitors of parasite PKG for the discovery of anticoccidial leads. Terferol (1) and three new terphenyls (2, 3, and 4) were isolated using bioassay-guided fractionation of the… CONTINUE READING