Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action.

@article{Zakrzewska2005HighlySM,
  title={Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action.},
  author={Malgorzata Zakrzewska and Daniel Krowarsch and Antoni Wiedlocha and Sjur Olsnes and Jacek Otlewski},
  journal={Journal of molecular biology},
  year={2005},
  volume={352 4},
  pages={860-75}
}
Fibroblast growth factor 1 (FGF-1) shows strong angiogenic, osteogenic and tissue-injury repair properties that might be relevant to medical applications. Since FGF-1 is partially unfolded at physiological temperature we decided to increase significantly its conformational stability and test how such an improvement will affect its biological function. Using an homology approach and rational strategy we designed two new single FGF-1 mutations: Q40P and S47I that appeared to be the most strongly… CONTINUE READING

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