Highly stable expression of a foreign gene from rabies virus vectors.

  title={Highly stable expression of a foreign gene from rabies virus vectors.},
  author={Teshome Mebatsion and Matthias J Schnell and James Hilton Cox and Stefan Finke and Karl Klaus Conzelmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 14},
A reverse genetics approach was applied to generate a chimeric nonsegmented negative strand RNA virus, rabies virus (RV) of the Rhabdoviridae family, that expresses a foreign protein. DNA constructs containing the entire open reading frame of the bacterial chloramphenicol acetyltransferase (CAT) gene and an upstream RV cistron border sequence were inserted either into the nontranslated pseudogene region of a full-length cDNA copy of the RV genome or exchanged with the pseudogene region. After… CONTINUE READING
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