Highly specific methyl-end fatty-acid desaturases of trypanosomatids.

@article{Alloatti2011HighlySM,
  title={Highly specific methyl-end fatty-acid desaturases of trypanosomatids.},
  author={Andr{\'e}s Alloatti and Antonio D. Uttaro},
  journal={Molecular and biochemical parasitology},
  year={2011},
  volume={175 2},
  pages={126-32}
}
A detailed analysis of the trypanosomatids' genome projects revealed the presence of genes predicted to encode fatty-acid desaturases of the methyl-end type (MED). After cloning and functional characterization of all identified genes, it can be concluded that Trypanosoma cruzi contains two MEDs with oleate desaturase (OD) activities whereas Leishmania major contains one OD and two active linoleate desaturases (LD). All characterized ODs are highly specific for oleate (18:1Δ9) as substrate… CONTINUE READING

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