Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

@article{Baba1989HighlySI,
  title={Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.},
  author={Masanori Baba and Hiroyuki Tanaka and Erik de Clercq and Rudi Pauwels and Jan Balzarini and Dominique Schols and Hideki Nakashima and C F Perno and R. T. Walker and Tomohiro Miyasaka},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={165 3},
  pages={1375-81}
}
A novel 6-substituted acyclouridine derivative, 1-[(2-hydroxy-ethoxy) methyl]-6-phenylthiothymine (HEPT), has proved to be a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro. HEPT inhibits HIV-1 replication in various T4 cell cultures as well as peripheral blood lymphocytes and macrophages. The 50% antiviral effective concentration for HIV-1 (HTLV-IIIB) in MT-4 cells is 7.0 microM, while the 50% cytotoxic concentration for mock-infected MT-4 cells is 740… CONTINUE READING

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