Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase.


Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases. 
DOI: 10.1039/c3ob40212f


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