Highly sensitive proximity mediated immunoassay reveals HER2 status conversion in the circulating tumor cells of metastatic breast cancer patients

  title={Highly sensitive proximity mediated immunoassay reveals HER2 status conversion in the circulating tumor cells of metastatic breast cancer patients},
  author={P. Kim and X. Liu and T. Lee and L. Liu and R. Barham and R. Kirkland and G. Leesman and Anne Kuller and B. Ybarrondo and Shi-Chung Ng and S. Singh},
  journal={Proteome Science},
  pages={75 - 75}
  • P. Kim, X. Liu, +8 authors S. Singh
  • Published 2011
  • Medicine, Biology
  • Proteome Science
  • BackgroundThe clinical benefits associated with targeted oncology agents are generally limited to subsets of patients. Even with favorable biomarker profiles, many patients do not respond or acquire resistance. Existing technologies are ineffective for treatment monitoring as they provide only static and limited information and require substantial amounts of tissue. Therefore, there is an urgent need to develop methods that can profile potential therapeutic targets with limited clinical… CONTINUE READING
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