Highly sensitive protein translation assay for trichothecene toxicity in airborne particulates: comparison with cytotoxicity assays.

@article{Yike1999HighlySP,
  title={Highly sensitive protein translation assay for trichothecene toxicity in airborne particulates: comparison with cytotoxicity assays.},
  author={Iwona Yike and Tamara Allan and William G. Sorenson and Dorr G. Dearborn},
  journal={Applied and environmental microbiology},
  year={1999},
  volume={65 1},
  pages={
          88-94
        }
}
Screening assays for environmental mycotoxins in bulk samples currently use cytotoxicity in cell cultures, but their application to air particulate samples often lacks sensitivity and specificity for fungal spores. An assay based on inhibition of protein synthesis using translation of firefly luciferase in a rabbit reticulocyte system has been developed for the detection of trichothecene mycotoxins found in the spores of toxigenic fungi. Ethanol extracts of air particulates trapped on… CONTINUE READING

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