Highly sensitive fluorescence in situ hybridization method to detect double BCR/ABL fusion and monitor response to therapy in chronic myeloid leukemia.

@article{Dewald1998HighlySF,
  title={Highly sensitive fluorescence in situ hybridization method to detect double BCR/ABL fusion and monitor response to therapy in chronic myeloid leukemia.},
  author={Gordon W. Dewald and William R. Wyatt and A L Juneau and Richard O Carlson and Alan R. Zinsmeister and Syed M Jalal and Jack L Spurbeck and Richard T. Silver},
  journal={Blood},
  year={1998},
  volume={91 9},
  pages={3357-65}
}
We investigated a new method using fluorescence in situ hybridization and DNA probes that span the common breakpoints of t(9;22)(q34;q11.2) and that detect double BCR/ABL fusion (D-FISH) in bone marrow cells with this translocation, one on the abnormal chromosome 9 and one on the Philadelphia chromosome (Ph chromosome). D-FISH patterns were abnormal in 30 of 30 specimens with classic, simple, complex, and masked Ph chromosomes. Based on 200 nuclei from each of 30 normal specimens, the mean… CONTINUE READING

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Chronic myelogenous leukemia.

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