Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres.

@article{Lee2012HighlySC,
  title={Highly selective CD44-specific gold nanorods for photothermal ablation of tumorigenic subpopulations generated in MCF7 mammospheres.},
  author={Eugene Lee and Yoochan Hong and Jihye Choi and Seungjoo Haam and Jin-Suck Suh and Yong-min Huh and Jaemoon Yang},
  journal={Nanotechnology},
  year={2012},
  volume={23 46},
  pages={
          465101
        }
}
Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods… CONTINUE READING

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