Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues.

@article{BestmanSmith2001HighlyRH,
  title={Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues.},
  author={Julie Bestman-Smith and Inga Schmit and Barbara Papadopoulou and Guy Boivin},
  journal={Journal of virology},
  year={2001},
  volume={75 7},
  pages={3105-10}
}
Clinical resistance of herpes simplex virus (HSV) types 1 and 2 to acyclovir (ACV) is usually caused by the presence of point mutations within the coding region of the viral thymidine kinase (TK) gene. The distinction between viral TK mutations involved in ACV resistance or part of viral polymorphism can be difficult to evaluate with current methodologies based on transfection and homologous recombination. We have developed and validated a new heterologous system based on the expression of the… CONTINUE READING
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