Highly regionalized neuronal expression of monocyte chemoattractant protein‐1 (MCP‐1/CCL2) in rat brain: Evidence for its colocalization with neurotransmitters and neuropeptides

@article{Banisadr2005HighlyRN,
  title={Highly regionalized neuronal expression of monocyte chemoattractant protein‐1 (MCP‐1/CCL2) in rat brain: Evidence for its colocalization with neurotransmitters and neuropeptides},
  author={Ghazal Banisadr and Romain-Daniel Gosselin and Patricia M{\'e}chighel and Patrick Kitabgi and William Rost{\`e}ne and St{\'e}phane M{\'e}lik Parsadaniantz},
  journal={Journal of Comparative Neurology},
  year={2005},
  volume={489}
}
The monocyte chemoattractant protein‐1 (MCP‐1/CCL2) and its receptor CCR2 are key modulators of immune functions. In the nervous system, MCP‐1/CCL2 is implicated in neuroinflammatory pathologies. However, cerebral functions of MCP‐1/CCL2 under normal conditions are still unclear. In this study, using reverse transcriptase‐polymerase chain reaction (RT‐PCR) and specific rat MCP‐1 enzyme‐linked immunosorbent assay (ELISA) approaches, we observed that MCP‐1/CCL2 mRNA and protein were expressed in… 
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Glial- and Neuronal-Specific Expression of CCL5 mRNA in the Rat Brain
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CCL2/CCR2 system in neuroepithelial radial glia progenitor cells: involvement in stimulatory, sexually dimorphic effects of maternal ethanol on embryonic development of hypothalamic peptide neurons
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Investigating in the embryo the developmental origins of this CCL2/CCR2-mediated stimulatory effect of maternal ethanol exposure on MCH neurons provides new evidence for how an inflammatory chemokine pathway functions within neuroprogenitor cells to mediate ethanol’s long-lasting, stimulatory effects on peptide neurons linked to adolescent drinking behavior.
TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment
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The findings suggest that TGFβ-1 signaling is an intriguing target to reduce neuroHIV, and rats treated with Nef showed deficits in spatial learning and memory in the novel location recognition task.
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