Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.

@article{Manesia2015HighlyPP,
  title={Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.},
  author={Javed Karim Manesia and Zhuofei Xu and Dorien Broekaert and Ruben Boon and Alex van Vliet and Guy Eelen and Thomas Vanwelden and Steve Stegen and Nick van Gastel and Alberto D. Pascual-Montano and Sarah-Maria Fendt and Geert Carmeliet and Peter Carmeliet and Satish Khurana and Catherine M. Verfaillie},
  journal={Stem cell research},
  year={2015},
  volume={15 3},
  pages={715-721}
}
Hematopoietic stem cells (HSCs) in the fetal liver (FL) unlike adult bone marrow (BM) proliferate extensively, posing different metabolic demands. However, metabolic pathways responsible for the production of energy and cellular building blocks in FL HSCs have not been described. Here, we report that FL HSCs use oxygen dependent energy generating pathways significantly more than their BM counterparts. RNA-Seq analysis of E14.5 FL versus BM derived HSCs identified increased expression levels of… CONTINUE READING
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Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

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