Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers.

@article{Liu2008HighlyPG,
  title={Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers.},
  author={Zhi Liu and Peng Hou and Meiju Ji and Haixia Guan and Kimberly Studeman and Kirk Jensen and Vasily V Vasko and A El-naggar and Mingzhao Xing},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 8},
  pages={3106-16}
}
CONTEXT Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-kinase (PI3K)/Akt and MAPK pathways have not been fully defined in anaplastic and follicular thyroid cancers [anaplastic thyroid cancer (ATC), follicular thyroid cancer (FTC)]. OBJECTIVE The objective of the study was to explore a wide-range genetic basis for the involvement of these pathways in ATC. DESIGN We examined mutations and copy number gains of a large panel of genes in these pathways and… CONTINUE READING
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