Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A.

@article{Zheleva2002HighlyPP,
  title={Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A.},
  author={Daniella I. Zheleva and Campbell McInnes and A-L Gavine and Nikolai Z Zhelev and Peter M. Fischer and D. P. Lane},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  year={2002},
  volume={60 5},
  pages={257-70}
}
The tumour suppressor protein p21(WAF1) plays a central role in regulating eukaryotic cell-cycle progression. Through its association with G1- and S-phase CDK complexes it regulates activation of the retinoblastoma protein (pRb) and E2F transcription factors. Recognition of CDK/cyclin complexes by p21 occurs, at least in part, through a protein-protein interaction with a binding groove on the cyclin subunit. The same groove has been shown to be involved in the recruitment of macromolecular CDK… CONTINUE READING