Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide.

@article{TalGan2013HighlyPI,
  title={Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide.},
  author={Yftah Tal-Gan and Danielle M Stacy and Mary K Foegen and David W. Koenig and Helen E Blackwell},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 21},
  pages={7869-82}
}
Methods to intercept bacterial quorum sensing (QS) have attracted significant attention as potential anti-infective therapies. Staphylococcus aureus is a major human pathogen that utilizes autoinducing peptide (AIP) signals to mediate QS and thereby regulate virulence. S. aureus strains are categorized into four groups (I-IV) according to their AIP signal and cognate extracellular receptor, AgrC. Each group is associated with a certain disease profile, and S. aureus group-III strains are… CONTINUE READING
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