Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities.

@article{Reiter2015HighlyPA,
  title={Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities.},
  author={Christoph Reiter and Tony Fr{\"o}hlich and Lisa Gruber and Corina Hutterer and Manfred Marschall and Cornelia Voigtl{\"a}nder and Oliver Friedrich and Barbara Kappes and Thomas H Efferth and Svetlana B. Tsogoeva},
  journal={Bioorganic & medicinal chemistry},
  year={2015},
  volume={23 17},
  pages={5452-8}
}
New pharmaceutically active compounds can be obtained by modification of existing drugs to access more effective agents in the wake of drug resistance amongst others. To achieve this goal the concept of hybridization was established during the last decade. We employed this concept by coupling two artemisinin-derived precursors to obtain dimers or trimers with increased in vitro activity against Plasmodiumfalciparum 3D7 strain, leukemia cells (CCRF-CEM and multidrug-resistant subline CEM/ADR5000… CONTINUE READING