Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.

@article{McGuigan2000HighlyPA,
  title={Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.},
  author={Christopher McGuigan and Hubert Barucki and Antonella Carangio and Sally A Blewett and Graciella Andrei and Robert Snoeck and Erik de Clercq and Jan Balzarini and Jonathan Thor Erichsen},
  journal={Journal of medicinal chemistry},
  year={2000},
  volume={43 26},
  pages={4993-7}
}
In addition to our recent report on the potent anti-varicella-zoster virus (VZV) activity of some unusual bicyclic furopyrimidine nucleosides bearing long alkyl side chains, we herein report the further significant enhancement of the antiviral potency by inclusion of a phenyl group in the side chain of these compounds. The target structures were prepared by the Pd-catalyzed coupling of a series of para-substituted arylacetylenes with 5-iodo-2'-deoxyuridine, to give intermediate 5-alkynyl… CONTINUE READING
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