Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia.

@article{Kornblau2010HighlyPF,
  title={Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia.},
  author={Steven M. Kornblau and Neera Singh and Yihua Qiu and W Chen and Nianxiang Zhang and Kevin R. Coombes},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 6},
  pages={1865-74}
}
PURPOSE The Forkhead transcription factors (FOXO) are tumor suppressor genes regulating differentiation, metabolism, and apoptosis that functionally interact with signal transduction pathways shown to be deregulated and prognostic in acute myelogenous leukemia (AML). This study evaluated the level of expression and the prognostic relevance of total and phosphorylated FOXO3A protein in AML. EXPERIMENTAL DESIGN We used reverse-phase protein array methods to measure the level of total and… CONTINUE READING

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