Highly pathogenic (H5N1) avian influenza induces an inflammatory T helper type 1 cytokine response in the chicken.

@article{Karpala2011HighlyP,
  title={Highly pathogenic (H5N1) avian influenza induces an inflammatory T helper type 1 cytokine response in the chicken.},
  author={Adam J. Karpala and John Bingham and Karel Antoni Schat and Limei Chen and Ruben O. Donis and John W. White Patrick R. Lowenthal and Andrew G D Bean},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2011},
  volume={31 4},
  pages={393-400}
}
To better understand the immune response to highly pathogenic avian influenza virus, we compared expression of cytokines in chickens infected with avian influenza virus (A/Vietnam/1203/04) to that in uninfected chickens. Gene expression analyses revealed that influenza disseminated to multiple organs where immune responses could be identified. Among those cytokines influenced by influenza infection were the T helper type (Th)1-associated cytokines interleukin (IL)12 and interferon γ. In… CONTINUE READING

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