Highly parallel identification of essential genes in cancer cells.

@article{Luo2008HighlyPI,
  title={Highly parallel identification of essential genes in cancer cells.},
  author={Biao Luo and Hiu Wing Cheung and Aravind Subramanian and Tanaz Sharifnia and Michael Okamoto and Xiaoping Yang and Greg Hinkle and Jesse S Boehm and Rameen Beroukhim and Barbara A. Weir and Craig H. Mermel and David Allen Barbie and Tarif Awad and Xiaochuan Zhou and Tuyen Viet Nguyen and Bruno Piqani and Cheng Yen Li and Todd R. Golub and Matthew Meyerson and Nir Hacohen and William C. Hahn and Eric S. Lander and David M. Sabatini and David E Root},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 51},
  pages={
          20380-5
        }
}
More complete knowledge of the molecular mechanisms underlying cancer will improve prevention, diagnosis and treatment. Efforts such as The Cancer Genome Atlas are systematically characterizing the structural basis of cancer, by identifying the genomic mutations associated with each cancer type. A powerful complementary approach is to systematically characterize the functional basis of cancer, by identifying the genes essential for growth and related phenotypes in different cancer cells. Such… CONTINUE READING

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