Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

@article{Giesen2014HighlyMI,
  title={Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry},
  author={Charlotte Giesen and Hao A. O. Wang and Denis Schapiro and Nevena Zivanovic and Andrea M Jacobs and Bodo Hattendorf and Peter J. Sch{\"u}ffler and Daniel Grolimund and Joachim M. Buhmann and Simone Brandt and Zsuzsanna Varga and Peter J. Wild and Detlef Guenther and Bernd Bodenmiller},
  journal={Nature Methods},
  year={2014},
  volume={11},
  pages={417-422}
}
Mass cytometry enables high-dimensional, single-cell analysis of cell type and state. In mass cytometry, rare earth metals are used as reporters on antibodies. Analysis of metal abundances using the mass cytometer allows determination of marker expression in individual cells. Mass cytometry has previously been applied only to cell suspensions. To gain spatial information, we have coupled immunohistochemical and immunocytochemical methods with high-resolution laser ablation to CyTOF mass… CONTINUE READING
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