Highly modular structure and ligand binding by conformational capture in a minimalistic riboswitch.

@article{DuchardtFerner2010HighlyMS,
  title={Highly modular structure and ligand binding by conformational capture in a minimalistic riboswitch.},
  author={Elke Duchardt-Ferner and Julia E Weigand and Oliver Ohlenschl{\"a}ger and Sina R. Schmidtke and Beatrix Suess and Jens W{\"o}hnert},
  journal={Angewandte Chemie},
  year={2010},
  volume={49 35},
  pages={
          6216-9
        }
}
Riboswitches are highly structured RNA motifs with gene regulatory activity located in the untranslated regions of mRNAs. They either modulate transcription termination or translation initiation through conformational changes triggered by direct interactions with small metabolite ligands. Many naturally occurring riboswitches are large and structurally very complex. In contrast, synthetic riboswitches—tailored gene regulatory elements for synthetic biology applications—are based on small in… CONTINUE READING
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