Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model.

@article{Grippo2000HighlyIT,
  title={Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model.},
  author={Paul J Grippo and Eric P. Sandgren},
  journal={The American journal of pathology},
  year={2000},
  volume={157 3},
  pages={805-13}
}
Transitional cell carcinoma (TCC), a neoplasm of urinary bladder urothelial cells, generally appears in either of two forms, papillary non-invasive or invasive TCC, although intermediate forms can occur. Each has a distinctive morphology and clinical course. Altered expression of the p53 and pRb genes has been associated with the more serious invasive TCC, suggesting that the loss of activity of these tumor suppressor proteins may have a causal role in this disease. To test this hypothesis… CONTINUE READING

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