Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector.

@article{Hirt1992HighlyIS,
  title={Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector.},
  author={R P Hirt and Odile Poulain-Godefroy and Jerome Billotte and Jean Pierre Kraehenbuhl and Nicolas Fasel},
  journal={Gene},
  year={1992},
  volume={111 2},
  pages={199-206}
}
A glucocorticoid-responsive vector is described which allows for the highly inducible expression of complementary DNAs (cDNAs) in stably transfected mammalian cell lines. This vector, pLK-neo, composed of a variant mouse mammary tumor virus long terminal repeat promoter, containing a hormone regulatory element, a Geneticin resistance-encoding gene in a simian virus 40 transcription unit, and a polylinker insertion site for heterologous cDNAs, was used to express the polymeric immunoglobulin… CONTINUE READING

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