Highly immunogenic and protective recombinant vaccine candidate expressed in transgenic plants.

@article{Chargelegue2005HighlyIA,
  title={Highly immunogenic and protective recombinant vaccine candidate expressed in transgenic plants.},
  author={Daniel M. Chargelegue and Pascal M. W. Drake and Patricia Launois Obreg{\'o}n and Alessandra Prada and Neil Thomas Fairweather and Julian K-C Ma},
  journal={Infection and immunity},
  year={2005},
  volume={73 9},
  pages={
          5915-22
        }
}
Vaccine development has been hampered by difficulties in developing new and safe adjuvants, so alternative technologies that offer new avenues forward are urgently needed. The goal of this study was to express a monoclonal recombinant immune complex in a transgenic plant. A recombinant protein consisting of a tetanus toxin C fragment-specific monoclonal antibody fused with the tetanus toxin C fragment was designed and expressed. Immune complex formation occurred between individual fusion… CONTINUE READING

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