Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue.

@article{Bhm2001HighlyEE,
  title={Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue.},
  author={Beate B B{\"o}hm and Thomas Aigner and Carl P Blobel and Joachim. R. Kalden and Harald Burkhardt},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 9},
  pages={2046-54}
}
OBJECTIVE The aim of the study was to analyze the expression of the disintegrin metalloproteinase MDC15 (metargidin, or ADAM15) at the messenger RNA (mRNA) and protein levels in synovial tissue from osteoarthritis (OA) and rheumatoid arthritis (RA) patients compared with normal specimens. METHODS Conventional immunohistochemistry and confocal laser scanning microscopy of immunofluorescently stained sections, as well as in situ hybridization experiments and reverse transcription-polymerase… CONTINUE READING

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