Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells.

@article{Baba2008HighlyEE,
  title={Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells.},
  author={Masanori Baba and Mika Okamoto and Takayuki Hamasaki and Sawako Horai and Xin Wang and Yuji Ito and Yasuo Suda and Naomichi Arima},
  journal={Journal of virology},
  year={2008},
  volume={82 8},
  pages={3843-52}
}
Human T-lymphotropic virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL). In Japan, the number of HTLV-1 carriers is estimated to be 1.2 million and more than 700 cases of ATL have been diagnosed every year. Considering the poor prognosis and lack of curative therapy of ATL, it seems mandatory to establish an effective strategy for the treatment of ATL. In this study, we attempted to identify the cell surface molecules that will become suitable targets of antibodies for… CONTINUE READING

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