Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(ii)-catalyzed asymmetric cyclopropanation reaction.

@article{Chi2016HighlyES,
  title={Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(ii)-catalyzed asymmetric cyclopropanation reaction.},
  author={Yongjian Chi and Lihua Qiu and Xinfang Xu},
  journal={Organic & biomolecular chemistry},
  year={2016},
  volume={14 44},
  pages={10357-10361}
}
A chiral dirhodium(ii) carboxylate complex catalyzed enantioselective cyclopropanation reaction of N-Boc diazooxindoles with olefins, including aryl, alkyl, cyclic, and disubstituted olefins, under mild conditions is described. This reaction provides complementary access to the corresponding chiral spirocyclopropyloxindole products in good to high yields with good to excellent enantioselectivities.