Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products.

@article{Antonchick2010HighlyES,
  title={Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products.},
  author={Andrey P Antonchick and Claas Gerding-Reimers and Mario Catarinella and Markus Schuermann and Hans Preut and Slava Ziegler and Daniel Rauh and Herbert Waldmann},
  journal={Nature chemistry},
  year={2010},
  volume={2 9},
  pages={735-40}
}
In biology-oriented synthesis the underlying scaffold classes of natural products selected in evolution are used to define biologically relevant starting points in chemical structure space for the synthesis of compound collections with focused structural diversity. Here we describe a highly enantioselective synthesis of natural-product-inspired 3,3'-pyrrolidinyl spirooxindoles--which contain an all-carbon quaternary centre and three tertiary stereocentres. This synthesis takes place by means of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Spirooxindoles: Promising scaffolds for anticancer agents.

European journal of medicinal chemistry • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Asymmetric syntheses of oxindole and indole spirocyclic alkaloid natural products

B. M. Trost, M. K. Brennan
Synthesis • 2009

Natural products in drug discovery.

Drug discovery today • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…