Highly enantioselective hydrogenation of 1-alkylvinyl benzoates: a simple, nonenzymatic access to chiral 2-alkanols.


Going chiral! Highly enantioselective catalytic hydrogenations of enol esters 1 by using a Rh catalyst bearing a P-OP ligand are described (see scheme; NBD=norbornadiene). The catalytic system has a broad scope and allows the preparation of a wide range of chiral esters 2 bearing diverse alkyls or a benzyl group with high enantioselectivities. These esters… (More)
DOI: 10.1002/chem.201303500


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