Highly enantioselective catalytic alkyl propiolate addition to aliphatic aldehydes.

@article{Turlington2009HighlyEC,
  title={Highly enantioselective catalytic alkyl propiolate addition to aliphatic aldehydes.},
  author={Mark Turlington and Albert M DeBerardinis and Lin Pu},
  journal={Organic letters},
  year={2009},
  volume={11 11},
  pages={2441-4}
}
A novel H(8)BINOL-based chiral ligand (S)-3 is found to catalyze the alkyl propiolate addition to aliphatic aldehydes in the presence of ZnEt(2) and Ti(O(i)Pr)(4) at room temperature with excellent enantioselectivity (89-97% ee). 
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