Highly enantioselective and regioselective nickel-catalyzed coupling of allenes, aldehydes, and silanes.

Abstract

A complex derived from Ni(cod)2 and NHC-IPr catalyzes a three-component coupling reaction involving allenes, aldehydes, and organosilanes and transfers the axial chirality of the allene to a stereogenic center in the product with very high fidelity. An unexpected regioselectivity is observed; favored are allylic rather than homoallylic alcohol derivatives… (More)

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