Highly enantioselective alpha-chlorination of cyclic beta-ketoesters catalyzed by N,N'-dioxide using NCS as the chlorine source.

@article{Cai2010HighlyEA,
  title={Highly enantioselective alpha-chlorination of cyclic beta-ketoesters catalyzed by N,N'-dioxide using NCS as the chlorine source.},
  author={Yunfei Cai and Wentao Wang and Ke Shen and Jun Wang and Xiaolei Hu and Lili Lin and Xiaohua Liu and Xiaoming Feng},
  journal={Chemical communications},
  year={2010},
  volume={46 8},
  pages={1250-2}
}
A simple and highly efficient N,N'-dioxide organocatalyst system was developed for the asymmetric alpha-chlorination of cyclic beta-ketoesters using easily available NCS as the chlorine source to provide a series of optically active alpha-chloro-beta-ketoesters in excellent yields with 90-98% ee.