Highly enantioselective addition of ketones to nitroolefins catalyzed by new thiourea-amine bifunctional organocatalysts.

Abstract

A new and effective organocatalytic system: primary amine derived chiral thiourea catalyst and AcOH-H2O additive, which converts different ketones to gamma-nitroketones in high yields (82-99%) and enantioselectivities (90-99%) has been described.

Cite this paper

@article{Tsogoeva2006HighlyEA, title={Highly enantioselective addition of ketones to nitroolefins catalyzed by new thiourea-amine bifunctional organocatalysts.}, author={Svetlana B Tsogoeva and Shengwei Wei}, journal={Chemical communications}, year={2006}, volume={13}, pages={1451-3} }