Highly enantioselective Ag(i)-catalyzed [3 + 2] cycloaddition of azomethine ylides.
@article{Longmire2002HighlyEA,
title={Highly enantioselective Ag(i)-catalyzed [3 + 2] cycloaddition of azomethine ylides.},
author={James M. Longmire and Bin Wang and Xumu Zhang},
journal={Journal of the American Chemical Society},
year={2002},
volume={124 45},
pages={
13400-1
}
}A highly reactive Ag(I)-catalyzed [3 + 2] cycloaddition of azomethine ylides is founded using AgOAc as the catalytic precursor and phosphines as ligands. Using a new bis-ferrocenyl amide phosphine (FAP) as the ligand, we found that high enantioselectivities (up to 97% ee) have been achieved in the [3 + 2] cycloaddition of azomethine ylides. Up to four stereogenic centers can be established in this multicomponent coupling reaction from readily available materials such as aldehydes, aminoesters…
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One Reference
Highly Enantioselective Ag(I)-Catalyzed [3 + 2] Cycloaddition of Azomethine Ylides
- 2002