Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan.

Abstract

A catalytic amount of TEMPO in the presence of PhI(OAc)(2) effected oxidative lactonization of 1,6- and 1,7-diols, directly affording seven- and eight-membered lactones, respectively, in good yields.

DOI: 10.1039/b919673k

Cite this paper

@article{Ebine2010HighlyES, title={Highly efficient synthesis of medium-sized lactones via oxidative lactonization: concise total synthesis of isolaurepan.}, author={Makoto Ebine and Yuto Suga and Haruhiko Fuwa and Makoto Sasaki}, journal={Organic & biomolecular chemistry}, year={2010}, volume={8 1}, pages={39-42} }