Highly efficient synthesis of flavonol 5-O-glycosides with glycosyl ortho-alkynylbenzoates as donors.

  title={Highly efficient synthesis of flavonol 5-O-glycosides with glycosyl ortho-alkynylbenzoates as donors.},
  author={Jinxi Liao and N. Fan and H. Liu and Yuan-Hong Tu and Jian-Song Sun},
  journal={Organic \& biomolecular chemistry},
  volume={14 4},
With glycosyl ortho-alkynylbenzoates as donors, the highly efficient glycosylation of flavonoid 5-OH which are notorious for their low reactivity due to their involvement in the formation of strong intramolecular H-bonds was achieved under the catalysis of a Au(i) complex. Thus, a series of flavonoid 5-O-glycosides, including a kaempferol 5-O-disaccharide, were synthesized with good to excellent yields. 
11 Citations
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