Highly efficient preparation of tumor antigen-containing glycopeptide building blocks from novel pentenyl glycosides.

Abstract

O-Glycosylated amino acids containing the tumor-associated T(Tf)-antigen (beta-D-Gal-(1-->3)-alpha-D-GalNAc) disaccharide unit were conveniently synthesized in seven steps starting from D-galactose via an n-pentenyl glycoside (NPG) building block. Azidonitration of 3,4,6-tri-O-acetyl-D-galactal, followed by nitrate displacement with simultaneous acetate… (More)

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Cite this paper

@article{Svarovsky2003HighlyEP, title={Highly efficient preparation of tumor antigen-containing glycopeptide building blocks from novel pentenyl glycosides.}, author={Serge A Svarovsky and Joseph J. Barchi}, journal={Carbohydrate research}, year={2003}, volume={338 19}, pages={1925-35} }