Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.

@article{AnokyeDanso2011HighlyEM,
  title={Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.},
  author={Frederick Anokye-Danso and Chinmay M Trivedi and Denise Juhr and Mudit Gupta and Zheng Cui and Ying Tian and Yuzhen Zhang and Wenli Yang and Peter J Gruber and Jonathan A. Epstein and Edward E Morrisey},
  journal={Cell stem cell},
  year={2011},
  volume={8 4},
  pages={
          376-88
        }
}
Transcription factor-based cellular reprogramming has opened the way to converting somatic cells to a pluripotent state, but has faced limitations resulting from the requirement for transcription factors and the relative inefficiency of the process. We show here that expression of the miR302/367 cluster rapidly and efficiently reprograms mouse and human somatic cells to an iPSC state without a requirement for exogenous transcription factors. This miRNA-based reprogramming approach is two orders… CONTINUE READING
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Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells.

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