Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery

@inproceedings{Wang2016HighlyEH,
  title={Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery},
  author={Jianbin Wang and Joshua J. DeClercq and Samuel B. Hayward and Patrick Wai-Lun Li and David A. Shivak and Philip D. Gregory and Gary P Lee and Michael C. Holmes},
  booktitle={Nucleic acids research},
  year={2016}
}
The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise in recent clinical trials. Nuclease-driven genome editing provides a method in which to precisely target genetic changes to further enhance T cell function in vivo. We describe the development of a highly efficient method to genome edit both primary human CD8 and CD4 T cells by homology-directed repair at a pre-defined site of the… CONTINUE READING
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