Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease.

@article{Stepniak2006HighlyEG,
  title={Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease.},
  author={Dariusz T Stepniak and Liesbeth Spaenij-Dekking and Cristina Mitea and Martine Moester and Arnoud H. de Ru and Ren{\'e}e F. Baak-Pablo and Peter A. van Veelen and Luppo Edens and Frits Koning},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={291 4},
  pages={
          G621-9
        }
}
Celiac disease is a T cell-driven intolerance to wheat gluten. The gluten-derived T cell epitopes are proline-rich and thereby highly resistant to proteolytic degradation within the gastrointestinal tract. Oral supplementation with prolyl oligopeptidases has therefore been proposed as a potential therapeutic approach. The enzymes studied, however, have limitations as they are irreversibly inactivated by pepsin and acidic pH, both present in the stomach. As a consequence, these enzymes will fail… Expand
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The ability of a single enzyme to greatly reduce the antigenic burden of grocery store gluten reinforces the case for developing oral peptidase therapy against Celiac Sprue. Expand
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