Highly efficient generation of airway and lung epithelial cells from human pluripotent stem cells

@inproceedings{Huang2014HighlyEG,
  title={Highly efficient generation of airway and lung epithelial cells from human pluripotent stem cells},
  author={Sarah X. L. Huang and Mohammad Naimul Islam and John C. O’Neill and Zheng Hu and Yong-Guang Yang and Ya-Wen Chen and Melanie D Mumau and Michael Green and Gordana Vunjak-Novakovic and Jahar Bhattacharya and H. -W. Snoeck},
  booktitle={Nature Biotechnology},
  year={2014}
}
The ability to generate lung and airway epithelial cells from human pluripotent stem cells (hPSCs) would have applications in regenerative medicine, modeling of lung disease, drug screening and studies of human lung development. We have established, based on developmental paradigms, a highly efficient method for directed differentiation of hPSCs into lung and airway epithelial cells. Long-term differentiation of hPSCs in vivo and in vitro yielded basal, goblet, Clara, ciliated, type I and type… CONTINUE READING